Aspirin, also known as acetylsalicylic acid, is a widely used over-the-counter pain reliever and anti-inflammatory medication. It is commonly used to reduce fever, inflammation, and pain in a variety of ailments such as headache, muscle pain, toothache, and arthritis.
Aspirin belongs to the family of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting the production of prostaglandins, which are chemicals that cause inflammation and pain in the body.
In this lab report, we will discuss the synthesis of aspirin from salicylic acid and acetic anhydride, as well as the characterization and purity testing of the final product.
To synthesize aspirin, salicylic acid and acetic anhydride are mixed together in the presence of a small amount of phosphoric acid, which acts as a catalyst. The mixture is then heated for about an hour. Upon completion, the mixture is cooled and the solid aspirin is collected by filtration.
The purity of the synthesized aspirin was tested using thin layer chromatography (TLC). TLC is a technique used to separate and identify compounds in a mixture. The aspirin sample was applied to a TLC plate and then placed in a solvent, which caused the compounds to move up the plate at different rates. The distance that each compound traveled was compared to standards to determine the purity of the sample.
The synthesized aspirin was also characterized using infrared spectroscopy (IR). IR is a technique used to identify functional groups in a molecule by measuring the vibrations of bonds within the molecule. The IR spectrum of the synthesized aspirin was compared to a known standard to confirm the presence of the expected functional groups.
The results of the TLC and IR analyses showed that the synthesized aspirin was pure and had the expected characteristics.
Overall, the synthesis of aspirin was successful, and the purity of the final product was confirmed through TLC and IR analysis. Aspirin is a widely used and effective medication, and understanding its synthesis and purity is important for its quality control and safe use.
1: Synthesis of Aspirin (Experiment)
The mass of salicylic acid is: 7. Water is added once removed from heat with addition of cold water and suction filtration is carried out. As the mixture cools, crystals of aspirin should form in the flask. Because the sample volume is 100 mL, the molar amount of salicylic acid impurity in the aspirin sample is 1. This must be done within 10 minutes of completing Step 22.
Check the control knob on the Melt Station to confirm that it is in the Off position. The regression line should closely fit the five data points and pass through or near the origin of the graph. Both substances can cause painful burns if they come in contact with the skin. The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. Filter the mixture with vacuum suction. Record the concentration of salicylic acid in your data table.
These Analgesics are compounds used to reduce pain, antipyretics are compounds used to reduce fever. Esterification reaction is used in the manufacture of paints, varnishes, lacquers, medicines, dyes, soaps and synthetic rubber. Add distilled water, as needed, to fill the flask to the 250 mL mark. Ethanol: Fire risk flash point 14. It is also useful in organic chemistry for the test of alcohols and carboxylic acid. A small amount of the solid will be pushed up into the tube. Additional 40mL of cold water is added.
Synthesis and Recrystallization of Aspirin Lab Report
A small amount of a strong acid is used as a catalyst which speeds up the reaction. Stop data collection to view a graph of absorbance vs. Tap the closed end of the capillary tube on the table top to compress the sample into the closed end. When most of the liquid has been drawn through the funnel, turn off the suction and wash the crystals with 5 mL of cold, distilled water. Over history, many compounds obtained from nature have been used to cure ills or to produce an effect in humans. The absorbance of the aspirin sample is 0.
Measure the melting temperature of your aspirin sample. Wash the crystals with cold, distilled water twice more in this manner. This might have affected the results. The hazard information reference is Sigma-Aldrich Co. In addition, there was a larger different in mass between the Bayer and Alka-Seltzer, which required more sodium hydroxide in the reaction. The blue light will turn on indicating that the fan is cooling the Melt Station. The melting temperature range of aspirin according to my experiment is between 134.
Filter the mixture with vacuum suction. When the absorbance value displayed on the screen has stabilized, select Keep and enter the molar concentration. Secondly, once we have dissolved and during the second round suction filtration in attempt to obtain the pure aspirin, we forgot to use 2 filter papers but instead use only one on the Buchner funnel. Ask instructor to assist with thecleaning ofany spills. This will be the catalyst for the reaction.
In this experiment, sulfuric acid will be used as the catalyst. How does the melting temperature test of your aspirin compare to the accepted value? Therefore, according to my results, the aspirin obtained is relatively impure. If the absorbance value falls within the range of the salicylic acid standard solutions, record it in your data table. Alka — Seltzer Bayer 13. Leave the Trial 1 cuvette in the Spectrophotometer and start data collection. Prepare the synthesized aspirin sample for testing. The calculations were repeated for each trial for each tablet.
Discard all solutions as directed. Each lab team will use about 2 g of salicylic acid. Use a previously prepared sample in a capillary tube, as described in Step 8, to determine the melting temperature of the sample: a. Then put this beaker in an ice-water bath. The experimentally determined melting temperature of 132. The Synthesis and Analysis of Aspirin Acetylsalicylic acid is the chemical name for aspirin, the ubiquitous pain reliever.
Synthesis and Recrystallization of Aspirin Lab Report
Steps 22—25 will guide you through the set up and testing of your aspirin sample. Suction filtration is carried out and the collected crude product after washing it a little with cold water. Make sure that the resulting solution is acidic blue litmus paper and that the aspirin has completely precipitated out. Calculate the percent yield of your synthesis. The experimental yield percentage is different from the theoretical percentage is because there is loss of product often occurring during the isolation and purification steps. You are now ready to collect data for the five standard solutions.
For the sample data, the mass of synthesized aspirin is 1. When the solid begins to melt, click Mark to mark the temperature on your graph. . The reaction equation is shown below. This will be the catalyst for the reaction.